@article{oai:iwate-pu.repo.nii.ac.jp:00001940,
 author = {千葉, 啓子 and CHIBA, Keiko},
 journal = {岩手県立大学盛岡短期大学部研究論集, Bulletin of Morioka Junior College Iwate Prefectural University},
 month = {Mar},
 note = {This paper reviews the recent findings regarding the metabolism of arsenic and arsenic-induced gene toxicity and carcinogenesis. It also reported the world-wide trend of the industrial production and demand of available arsenic compounds. Because people perceive arsenic as a harmful element, they think the availability of these compounds is scarce. Until the present time, arsenic compounds have been used for the purposes of industry, agriculture, and as food additives for domestic animals to increase body weight. In recent decades, demand of arsenical metalloid increase for the semiconductor materials, especially in Japan. Since last year, arsenic compounds have been demonstrated to be scientifically effective as anticancer agents and have been used in the treatment of promyelocytic leukemia. With the recent studies, there are two advances on the methylation of inorganic arsenic. One of them supports the present advance that the methylation acts as a detoxification mechanism, because the cytotoxic effects of methylated arsenic compounds investigated are lower than inorganic arsenicals. Methylated arsenic compounds induced 100% of cell death as apoptosis. Other study also describes dimethylarsinic acid (DMA) requires intracellular reduced glutathione (GSH) before induction of apoptosis. The second advance states that methylated arsenicals act more toxic than inorganic arsenic. DMA as an oxidative stress, produced the dimethylarsenic radical and dimethylarsenic peroxy radical and these radicals induced genotoxicity and carcinogenecity. Another study also proposes that DNA hypomethylation was caused by the consumption of the methylation of inorganic arsenic and carcinogenic effects that were produced. Furthermore, it demonstrates that methylated trivalent arsenic species were significantly more cytotoxic, and that those compounds are detected in the human urine of the chronic arsenic poisoning patients both in China and West Bengal. These results indicate a need to reevaluate the hypothesis that the methylation of inorganic arsenic is a detoxification mechanism. These studies suggest that role of intracellular GSH is very important for the methylation of inorganic arsenic in mammals., 3, KJ00000704062, 総説, Review},
 pages = {1--11},
 title = {砥素研究の新たな方向},
 volume = {4},
 year = {2002},
 yomi = {チバ, ケイコ}
}