{"created":"2023-06-19T10:37:40.135250+00:00","id":1762,"links":{},"metadata":{"_buckets":{"deposit":"b87e4288-4968-40f2-a74a-152429793cf6"},"_deposit":{"created_by":16,"id":"1762","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"1762"},"status":"published"},"_oai":{"id":"oai:iwate-pu.repo.nii.ac.jp:00001762","sets":[]},"author_link":["3160","3161","3162","3163","3164","3165"],"item_7_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"36","bibliographicPageStart":"23","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"岩手県立大学看護学部紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of the Faculty of Nursing, Iwate Prefectural University","bibliographic_titleLang":"en"}]}]},"item_7_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"肝外合併症を有さないインターフェロン未治療のC型慢性肝炎36例を対象とし、潜在性甲状腺障害の実態を検討した。対象の内訳は男性13例、女性23例、年齢は32～77歳(中央値62.5歳)～、ALT値の平均は60.8IU/L(8～188 IU/L)、である。 FT4低値例を5.6%に認め、うち1例はTSHが明らかに高値で甲状腺機能低下症と診断された。TSH異常を22.2%に認め、多くが高値例でいずれも女性であった。TRAbおよびTg-Abはそれぞれ16.7%に検出された。ミクロソームテストは9.1%、TPO-Abは5.9%が陽性であった。血中Tg高値例を25.0%に認めた。全体としていずれかの甲状腺自己抗体が陽性か、あるいはTg高値の例は33.3%であり、一般人口に比し高値の傾向であった。潜在性甲状腺機能障害例の多くは機能低下症で女性に多かった。事実われわれも、ペグインターフェロン治療により融性および不顕性の甲状腺機能低下症を発症した症例を各1例経験した。ペグインターフェロン治療により潜在性甲状腺障害が顕性化する可能性が示唆され、特に治療前甲状腺自己抗体陽性例は、治療開始後も定期的に厳重な甲状腺機能のチェックが必要で、機能悪化を認めた場合は速やかに投与を中止し加療することが重要と考えられた。","subitem_description_type":"Other"}]},"item_7_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The present study investigated latent thyroid disorders in 36 patients (13 men; 23 women; ages ranging from 32 to 77 years; median, 62.5 years) with chronic hepatitis C who did not have extrahepatic complications and had not previously received interferon. The average ALT for the subjects was 60.8 IU/L (range: 8-188 IU/L). Low FT4 was seen in 5.6%, and one patient clearly had high TSH and was diagnosed as having hypothyroidism. TSH abnormalities were seen in 22.2 % ; most patients had high TSH and were women. TRAb and TG-Ab were detected in 16.7% each, microsome test in 9.1%, and TPO-Ab in 5.9%. High Tg was seen in 25.0%. Among the entire subjects, the prevalence of positive thyroid autoantibodies or high Tg was 33.3% , which is higher than in the general population. Most patients with latent thyroid dysfunction had hypo function and were women. A biological response modifier such as peginterferon for treatment of chronic hepatitis C may render a latent thyroid disorder overt. In fact we encountered two patients who developed hyperthyroidism during or after administration of peginterferon. These results suggest that periodic and careful thyroid function tests are required in patients with thyroid autoantibody prior to the start of interferon therapy. Any evidence of thyroid function exacerbation requires immediate cessation of interferon administration and appropriate counter-therapy.","subitem_description_type":"Other"}]},"item_7_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"5","subitem_description_type":"Other"}]},"item_7_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00005384819","subitem_description_type":"Other"}]},"item_7_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_7_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original Article","subitem_description_type":"Other"}]},"item_7_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11373559","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13449745","subitem_source_identifier_type":"PISSN"}]},"item_7_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Faculty of Nursing, Iwate Prefectural University"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Nursing, Iwate Prefectural University"},{"subitem_text_language":"en","subitem_text_value":"Iwate Seiwa Hospital"},{"subitem_text_language":"en","subitem_text_value":"Health Administration Center, Iwate Medical University"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Nursing, Iwate Prefectural University"},{"subitem_text_language":"en","subitem_text_value":"Chugai Pharmaceutical Company"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Kazuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nitatori, Tohru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakakarumai, Chihoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isobe, Naoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zushi, Natsuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3165","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-12-27"}],"displaytype":"detail","filename":"KJ00005384819.pdf","filesize":[{"value":"964.6 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"KJ00005384819.pdf","objectType":"fulltext","url":"https://iwate-pu.repo.nii.ac.jp/record/1762/files/KJ00005384819.pdf"},"version_id":"b76ff4e5-fa50-47a6-b9a2-0a591bf96278"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"thyroidautoantibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroid dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatitis C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peginterferon","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroglobulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Latent thyroid dysfunction in patients with chronic hepatitis C virus infection and its relevance to emergence of symptoms after peg-interferon treatment","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Latent thyroid dysfunction in patients with chronic hepatitis C virus infection and its relevance to emergence of symptoms after peg-interferon treatment","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["271"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-12-27"},"publish_date":"2016-12-27","publish_status":"0","recid":"1762","relation_version_is_last":true,"title":["Latent thyroid dysfunction in patients with chronic hepatitis C virus infection and its relevance to emergence of symptoms after peg-interferon treatment"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-06-21T00:56:55.823046+00:00"}